Study

Sequence-audited comparative genomics of genome-maintenance genes in vertebrate lifespan evolution

Processed data and frozen outputs supporting the manuscript “Sequence-audited comparative genomics of genome-maintenance genes in vertebrate lifespan evolution.” The archive includes source data for four main figures, 41 supplementary data tables, a dated species tree, protein alignments, gene-family trees, a reproducibility guide, and SHA-256 checksums.

Abstract

Processed data and frozen outputs supporting the manuscript “Sequence-audited comparative genomics of genome-maintenance genes in vertebrate lifespan evolution.” The archive includes source data for four main figures, 41 supplementary data tables, a dated species tree, protein alignments, gene-family trees, a reproducibility guide, and SHA-256 checksums. Analysis code is available at https://github.com/jackeikee-debug/nature-bird-lifespan, release v1.0.0.

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Result tables50
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Repositories1
Result tables50
Charts37
Released figures18
Source datasets50
Complete tables50

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The preserved source contains 50 result tables; 50 have complete deterministic representation coverage.

Supplementary Data 34 Audited Gene Selection source data

10 materialized released rows from submission:submission-0874a5a043ddb0a424e0af00:1/nature-bird-lifespan-data-v1.0.0.zip!/Supplementary_Data/Supplementary_Data_34_audited_gene_selection.tsv.

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Supplementary Data 34 Audited Gene Selection source data

10 materialized released rows from submission:submission-0874a5a043ddb0a424e0af00:1/nature-bird-lifespan-data-v1.0.0.zip!/Supplementary_Data/Supplementary_Data_34_audited_gene_selection.tsv.

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Rescue RankHuman Gene SymbolSubmodule V2Orthology Validation PriorityGene Family RiskV2 Scoring GroupClaim UseAudited Low Coverage Bird SpeciesAudited Species Gene RowsPre Rescue Selection BasisPosthoc Protein Or Domain Result Used
1DNMT1repeat_chromatin_repressionhighmodule_high_prioritycrossdb_confirmnot_main_until_confirmed1414High orthology-validation priority in the transposon/repeat module; selected in a fixed rescue order for low-observability avian rows with module-high-priority or paralog/family riskFalse
2DNMT3Arepeat_chromatin_repressionhighmodule_high_prioritycrossdb_confirmnot_main_until_confirmed1414High orthology-validation priority in the transposon/repeat module; selected in a fixed rescue order for low-observability avian rows with module-high-priority or paralog/family riskFalse
3DNMT3Brepeat_chromatin_repressionhighmodule_high_prioritycrossdb_confirmnot_main_until_confirmed1414High orthology-validation priority in the transposon/repeat module; selected in a fixed rescue order for low-observability avian rows with module-high-priority or paralog/family riskFalse
4HELLSrepeat_chromatin_repressionhighmodule_high_prioritycrossdb_confirmnot_main_until_confirmed1414High orthology-validation priority in the transposon/repeat module; selected in a fixed rescue order for low-observability avian rows with module-high-priority or paralog/family riskFalse
5UHRF1repeat_chromatin_repressionhighmodule_high_prioritycrossdb_confirmnot_main_until_confirmed1414High orthology-validation priority in the transposon/repeat module; selected in a fixed rescue order for low-observability avian rows with module-high-priority or paralog/family riskFalse
6SETDB2repeat_chromatin_repressionhighmodule_high_prioritycrossdb_confirmnot_main_until_confirmed1414High orthology-validation priority in the transposon/repeat module; selected in a fixed rescue order for low-observability avian rows with module-high-priority or paralog/family riskFalse
7MBD2repeat_chromatin_repressionhighmodule_high_prioritycrossdb_confirmnot_main_until_confirmed1414High orthology-validation priority in the transposon/repeat module; selected in a fixed rescue order for low-observability avian rows with module-high-priority or paralog/family riskFalse
8MBD3repeat_chromatin_repressionhighmodule_high_prioritycrossdb_confirmnot_main_until_confirmed1414High orthology-validation priority in the transposon/repeat module; selected in a fixed rescue order for low-observability avian rows with module-high-priority or paralog/family riskFalse
9MORC3somatic_retroelement_restrictionhighhigh_paralog_familycrossdb_confirmnot_main_until_confirmed1414High orthology-validation priority in the transposon/repeat module; selected in a fixed rescue order for low-observability avian rows with module-high-priority or paralog/family riskFalse
10SAMHD1somatic_retroelement_restrictionhighmodule_high_prioritycrossdb_confirmnot_main_until_confirmed1414High orthology-validation priority in the transposon/repeat module; selected in a fixed rescue order for low-observability avian rows with module-high-priority or paralog/family riskFalse
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Supplementary Data 35 Matched Random Gene Set Null source data

10000 materialized released rows from submission:submission-0874a5a043ddb0a424e0af00:1/nature-bird-lifespan-data-v1.0.0.zip!/Supplementary_Data/Supplementary_Data_35_matched_random_gene_set_null.tsv.

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Supplementary Data 35 Matched Random Gene Set Null source data

10000 materialized released rows from submission:submission-0874a5a043ddb0a424e0af00:1/nature-bird-lifespan-data-v1.0.0.zip!/Supplementary_Data/Supplementary_Data_35_matched_random_gene_set_null.tsv.

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Target ModuleSample SizeMean Gene CoverageCoverage DistanceEstimatePRR2Sampled GenesPermutation Id
chromatin_repression_heterochromatin300.70441176470588230.00.243897972383530060.0113504307352171750.305308061772470550.0932130125832627ERCC1,PTEN,RECQL4,ISG15,SIRT1,BNIP3,SERPINE1,CDKN1B,GPX1,SOCS3,TERF2,IL1B,ATG12,ERCC3,SMC1A,TERT,DNM1L,FAS,MDM2,PARP2,MRE11,BRCA2,CDKN2B,NFKB1,GABARAPL1,BAK1,APEX1,DNAJA1,CDKN2A,SOD21
chromatin_repression_heterochromatin300.70441176470588230.00.257604240818020860.008222740987430240.318014339152826730.10113311990680911XPA,HSP90AA1,USP18,TP53BP1,LMNB1,MB21D1,ERCC1,GPX1,UBB,TBK1,CDKN2A,XRCC3,NLRX1,RTEL1,POT1,NLRP3,RB1,PIN1,ERCC2,ADAR,BNIP3,STAG2,ISG15,FAS,PARP2,OPA1,ERCC5,GLB1,OPTN,SIRT62
chromatin_repression_heterochromatin300.70441176470588230.00.246261717641777820.0111601770848409830.305987697337565150.09362847092194537ATG4B,BAG3,RAD50,OPTN,XRCC1,NLRP3,DNAJB1,UBB,GABARAPL1,IL1B,MRE11,ATG7,TERC,CHEK1,ERCC2,NLRX1,ACD,FAS,ATG10,DNM1L,ATR,UBE2N,UBE2D1,HSP90AA1,TERT,BECN1,IRF3,GLB1,XPC,CDKN2B3
chromatin_repression_heterochromatin300.70441176470588230.00.260394021511600240.0100559223936352930.31014353438264540.09618901191935916ATG3,BRCA2,XRCC5,ERCC4,CDKN2A,FUNDC1,RB1,ATG7,APEX1,MUTYH,NLRP3,IRF3,TP53,OPA1,ATG4B,MDM2,ISG15,RELA,TBK1,ADARB1,ERCC5,BAX,XRCC4,MAVS,STAG2,GLB1,PPARG,H2AX,TNFAIP3,DNAJA14
chromatin_repression_heterochromatin300.70441176470588230.00.249211996636005020.0081915885060725880.318160858116621760.10122633163750512TNFAIP3,ACD,XRCC4,TNF,IFIH1,RELA,FOXO3,PIN1,BECN1,ATM,PARP1,APEX1,RTEL1,STING1,TP53,BNIP3L,CHEK1,SMC1A,ATG16L1,DNM1L,CDKN2A,PRKDC,OGG1,XPA,ATG3,ISG15,UBB,IRF3,UBE2N,NFKBIA5
chromatin_repression_heterochromatin300.70441176470588230.00.255771088085843150.00740894460202852750.32201197151447320.1036917097986379ATM,APEX1,LIG4,PRKN,VCP,BRIP1,NHEJ1,BAG1,ADARB1,ERCC1,SOCS1,SOCS3,TINF2,TNF,STING1,ATG4B,BECN1,TERF2,HSPA8,TNFAIP3,UBE2N,IKBKB,RB1,CDKN2B,TBK1,H2AX,LIG3,CDKN2A,SMC1A,DKC16
chromatin_repression_heterochromatin300.70441176470588230.00.265797469559012340.0089360936213169450.31478526166040850.09908976095861184PTEN,PPARG,NLRC3,WRN,ACD,GLB1,TNFAIP3,BAG3,MFN2,DNAJB1,PARP2,GPX1,ERCC1,RECQL4,NLRP3,MFN1,DNAJA1,BRCA1,ADARB1,BNIP3L,XPC,BCL2L1,PRKN,PINK1,ISG15,PYCARD,IL1B,APEX1,CDKN2A,ATG4B7
chromatin_repression_heterochromatin300.70441176470588230.00.23398369021409390.0102849978183022930.309249891436998050.09563549535379508CDKN2B,ATG4B,CDKN1A,CDKN2A,XRCC4,CYLD,TNFAIP3,BAG1,ATG10,WRN,SQSTM1,ADAR,PARP2,PRKDC,TBK1,FOXO3,NFKB1,UBE2N,STAG2,ATG16L1,ERCC2,GPX1,H2AX,GADD45A,XPC,ATG12,CHEK1,MAP1LC3B,DKC1,FAS8
chromatin_repression_heterochromatin300.70441176470588230.00.25290269268324750.0101376171689495160.309822823422046260.09599018191320846PTEN,BRCA1,HSF1,IRF3,DNM1L,STING1,RECQL4,PSMB5,ERCC3,DNAJA1,SERPINE1,TERF2,SIRT1,TP53BP1,PALB2,PIN1,HSPA8,DNAJB1,CDKN2B,UBC,FOXO3,NLRP3,TERC,TNFAIP3,DKC1,UBE2D1,ATG12,IKBKB,LMNB1,GABARAPL19
chromatin_repression_heterochromatin300.70441176470588230.00.28235800905996390.0092543604285212560.313416698339348270.09823002679793803CDKN1A,SOD2,XPC,ERCC3,CDKN2B,H2AX,ATG7,SIRT1,BAG3,TP53BP1,TERC,RTEL1,CHEK2,MB21D1,MFN2,UBC,XRCC5,RECQL4,RELA,CDKN2A,GPX1,ERCC2,DKC1,OPTN,NLRC3,UBE2D1,RB1,WRN,TERF1,RAD5110
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Supplementary Data 36 Module Weight Sensitivity Species source data

1224 materialized released rows from submission:submission-0874a5a043ddb0a424e0af00:1/nature-bird-lifespan-data-v1.0.0.zip!/Supplementary_Data/Supplementary_Data_36_module_weight_sensitivity_species.tsv.

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Supplementary Data 36 Module Weight Sensitivity Species source data

1224 materialized released rows from submission:submission-0874a5a043ddb0a424e0af00:1/nature-bird-lifespan-data-v1.0.0.zip!/Supplementary_Data/Supplementary_Data_36_module_weight_sensitivity_species.tsv.

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Weight SchemeHigh WeightMedium WeightLow WeightScientific NameOpentree Tip LabelCladeLog10 Body Mass GLog10 Max Lifespan YearsPgls Model C Mass Clade ResidualMaintenance ModuleGenes TotalGenes Observed LocalCoverage FractionModule ScoreExternal Sensitivity Rows Scored
conservative_1.0_0.7_0.251.00.70.25Agelaius phoeniceusAgelaius_phoeniceus_ott226605Aves1.75358305889290691.30102999566398130.246198779383737DNA_repair_replication_stress39360.92307692307692310.646153846153846False
conservative_1.0_0.7_0.251.00.70.25Ailuropoda melanoleucaAiluropoda_melanoleuca_ott872573Mammalia_nonChiroptera5.0700378666077561.56584781867351760.0700459324566742DNA_repair_replication_stress39380.97435897435897430.682051282051282False
conservative_1.0_0.7_0.251.00.70.25Alectura lathamiAlectura_lathami_ott570956Aves3.3692158574101431.0969100130080565-0.234108582567407DNA_repair_replication_stress3970.17948717948717950.04487179487179487False
conservative_1.0_0.7_0.251.00.70.25Alligator mississippiensisAlligator_mississippiensis_ott335590Reptilia3.03302144468291071.88649072517248180.497971433424552DNA_repair_replication_stress39380.97435897435897430.682051282051282False
conservative_1.0_0.7_0.251.00.70.25Alligator sinensisAlligator_sinensis_ott953151Reptilia4.1643528557844371.81291335664285550.230996494708646DNA_repair_replication_stress39360.92307692307692310.6230769230769229False
conservative_1.0_0.7_0.251.00.70.25Ammodramus caudacutusAmmodramus_caudacutus_ott567252Aves1.21748394421390651.00.0368132524762498DNA_repair_replication_stress39360.92307692307692310.646153846153846False
conservative_1.0_0.7_0.251.00.70.25Anas platyrhynchosAnas_platyrhynchos_ott765167Aves3.0086001717619171.46389298898590740.194520518225029DNA_repair_replication_stress39370.94871794871794870.6525641025641025False
conservative_1.0_0.7_0.251.00.70.25Anolis carolinensisAnolis_carolinensis_ott705356Reptilia0.39005149645898730.8573324964312685-0.0793793399184356DNA_repair_replication_stress39370.94871794871794870.664102564102564False
conservative_1.0_0.7_0.251.00.70.25Anseranas semipalmataAnseranas_semipalmata_ott714464Aves3.31618009889345271.39445168082621620.0724993824731792DNA_repair_replication_stress3980.205128205128205120.05128205128205128False
conservative_1.0_0.7_0.251.00.70.25Antrozous pallidusAntrozous_pallidus_ott913941Mammalia_Chiroptera1.34242268082220621.17026171539495750.0665069689343958DNA_repair_replication_stress3990.230769230769230780.057692307692307696False
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Supplementary Data 37 Module Weight Sensitivity Pgls source data

36 materialized released rows from submission:submission-0874a5a043ddb0a424e0af00:1/nature-bird-lifespan-data-v1.0.0.zip!/Supplementary_Data/Supplementary_Data_37_module_weight_sensitivity_pgls.tsv.

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Supplementary Data 37 Module Weight Sensitivity Pgls source data

36 materialized released rows from submission:submission-0874a5a043ddb0a424e0af00:1/nature-bird-lifespan-data-v1.0.0.zip!/Supplementary_Data/Supplementary_Data_37_module_weight_sensitivity_pgls.tsv.

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Weight SchemeMaintenance ModuleEndpointFormulaNLambdaEstimate Per Score SdSeConf LowConf HighTPErrorQ Within Scheme Endpoint
conservative_1.0_0.7_0.25cancer_surveillance_senescenceparallel_residualpgls_model_c_mass_clade_residual ~ score_z680.7927672570553830.07932873221624370.02809257050280280.02426729403075030.1343901704017372.82383316287590.006267808670868510.01165602654627
primary_1.0_0.8_0.5cancer_surveillance_senescenceparallel_residualpgls_model_c_mass_clade_residual ~ score_z680.7971321563476040.0802535533399170.02811601541480560.0251461631268980.1353609435529362.854371508761380.00575635187159240.0101166549756639
unweighted_local_presencecancer_surveillance_senescenceparallel_residualpgls_model_c_mass_clade_residual ~ score_z680.8030656802962610.08148669592593470.02814420915573440.02632404598069530.1366493458711742.895327258088250.005130759191568580.00883937924586693
conservative_1.0_0.7_0.25chromatin_repression_heterochromatinparallel_residualpgls_model_c_mass_clade_residual ~ score_z680.7865986503694420.07486052099302210.02718179637753580.02158420009305190.1281368418929922.754068198924850.007596906684755210.01165602654627
primary_1.0_0.8_0.5chromatin_repression_heterochromatinparallel_residualpgls_model_c_mass_clade_residual ~ score_z680.7863720111064250.07527690995082230.02711276565439330.02213588926821140.1284179306334332.776437893145160.007144938981195280.0101166549756639
unweighted_local_presencechromatin_repression_heterochromatinparallel_residualpgls_model_c_mass_clade_residual ~ score_z680.7859676865020270.07581833438383190.02701614644649630.02286668734869930.1287699814189652.806408180159420.006578071875249950.00883937924586693
conservative_1.0_0.7_0.25DNA_repair_replication_stressparallel_residualpgls_model_c_mass_clade_residual ~ score_z680.7898292887484710.07046387651674220.02715762420792020.01723493306921850.1236928199642662.594625950240230.011656026546270.01165602654627
primary_1.0_0.8_0.5DNA_repair_replication_stressparallel_residualpgls_model_c_mass_clade_residual ~ score_z680.7967074137972420.07223666644589250.0271254924711060.01907070120252470.125402631689262.663054561049490.009718899139201210.0101166549756639
unweighted_local_presenceDNA_repair_replication_stressparallel_residualpgls_model_c_mass_clade_residual ~ score_z680.8068189028533410.07478841949891920.02704500586889290.02178020799588920.1277966310019492.765331975207320.007366149371555770.00883937924586693
conservative_1.0_0.7_0.25inflammation_innate_immune_restraintparallel_residualpgls_model_c_mass_clade_residual ~ score_z680.7687681208907810.07639676894316610.02878529780959760.01997758523635490.1328159526499772.654020446427130.00995662905024730.01165602654627
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Supplementary Data 38 Samhd1 Alignment Position Qc source data

626 materialized released rows from submission:submission-0874a5a043ddb0a424e0af00:1/nature-bird-lifespan-data-v1.0.0.zip!/Supplementary_Data/Supplementary_Data_38_samhd1_alignment_position_qc.tsv.

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Supplementary Data 38 Samhd1 Alignment Position Qc source data

626 materialized released rows from submission:submission-0874a5a043ddb0a424e0af00:1/nature-bird-lifespan-data-v1.0.0.zip!/Supplementary_Data/Supplementary_Data_38_samhd1_alignment_position_qc.tsv.

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Human Reference ResidueAlignment Column 1basedReference Amino AcidDomain ClassTarget Sequence Gap FractionRetain OriginalRetain Max Gap 0.70Retain Max Gap 0.50
1191Mnon_domain0.5178571428571429TrueTrueFalse
2192Qnon_domain0.5TrueTrueTrue
3193Rnon_domain0.4642857142857143TrueTrueTrue
4194Anon_domain0.26785714285714285TrueTrueTrue
5195Dnon_domain0.26785714285714285TrueTrueTrue
6196Snon_domain0.26785714285714285TrueTrueTrue
7197Enon_domain0.14285714285714285TrueTrueTrue
8198Qnon_domain0.14285714285714285TrueTrueTrue
9199Pnon_domain0.14285714285714285TrueTrueTrue
10200Snon_domain0.14285714285714285TrueTrueTrue
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Supplementary Data 39 Samhd1 Alignment Species Qc source data

168 materialized released rows from submission:submission-0874a5a043ddb0a424e0af00:1/nature-bird-lifespan-data-v1.0.0.zip!/Supplementary_Data/Supplementary_Data_39_samhd1_alignment_species_qc.tsv.

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Supplementary Data 39 Samhd1 Alignment Species Qc source data

168 materialized released rows from submission:submission-0874a5a043ddb0a424e0af00:1/nature-bird-lifespan-data-v1.0.0.zip!/Supplementary_Data/Supplementary_Data_39_samhd1_alignment_species_qc.tsv.

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Alignment VariantScientific NameOpentree Tip LabelCladeAlignment Record IdSelected AccessionQualified Original Domain Coverage Ge 0.5Original Domain Reference CoveragePgls Model C Mass Clade ResidualWhole Reference ResiduesWhole Reference CoverageSam Reference ResiduesSam Reference CoverageHd Reference ResiduesHd Reference CoverageDomain Reference ResiduesDomain Reference CoverageDomain Aligned IdentityDomain Identity Coverage ProductNondomain Reference Residues
original_reference_positionsAgelaius phoeniceusAgelaius_phoeniceus_ott226605AvesS001XP_054500517.2True1.00.2461987793837376260.9536741214057508661.0641.01301.00.57692307692307690.5769230769230769496
original_reference_positionsAlectura lathamiAlectura_lathami_ott570956AvesS003NXL87263.1True0.7846153846153846-0.2341085825674076260.8801916932907349660.5757575757575758641.01300.78461538461538460.65686274509803920.5153846153846153496
original_reference_positionsAmmodramus caudacutusAmmodramus_caudacutus_ott567252AvesS006XP_058670767.1True1.00.03681325247624986260.950479233226837661.0641.01301.00.57692307692307690.5769230769230769496
original_reference_positionsAnas platyrhynchosAnas_platyrhynchos_ott765167AvesS007XP_027328695.2True1.00.1945205182250296260.9680511182108626661.0641.01301.00.62307692307692310.6230769230769231496
original_reference_positionsAnseranas semipalmataAnseranas_semipalmata_ott714464AvesS009NXI67288.1True0.73846153846153850.07249938247317926260.8706070287539937660.48484848484848486641.01300.73846153846153850.67708333333333340.5496
original_reference_positionsAtrichornis clamosusAtrichornis_clamosus_ott1031586AvesS013NXY12819.1False0.4923076923076923-0.1396120454475816260.8035143769968051660.0641.01300.492307692307692340.843750.4153846153846154496
original_reference_positionsBalearica regulorumBalearica_regulorum_ott191006AvesS015XP_075624428.1True1.00.07642587561057516260.9664536741214057661.0641.01301.00.56923076923076920.5692307692307692496
original_reference_positionsCaloenas nicobaricaCaloenas_nicobarica_ott1032058AvesS016XP_065501938.1True1.00.09254281308126536260.9648562300319489661.0641.01301.00.59230769230769230.5923076923076923496
original_reference_positionsCaprimulgus carolinensisAntrostomus_carolinensis_ott416426AvesS019XP_010171878.1True0.60769230769230760.06293018672175956260.84185303514377660.22727272727272727641.01300.60769230769230760.74683544303797470.4538461538461538496
original_reference_positionsCettia cettiCettia_cetti_ott1010418AvesS022NXV04450.1False0.49230769230769230.02130235074121326260.4904153354632588660.0641.01300.492307692307692340.843750.4153846153846154496
Complete inspected source table. Open the source and verification details below for the exact released file.
SHA-256 verified
Source & verification
File
submission:submission-0874a5a043ddb0a424e0af00:1/nature-bird-lifespan-data-v1.0.0.zip!/Supplementary_Data/Supplementary_Data_39_samhd1_alignment_species_qc.tsv
Version
released
Integrity
dd4745ec…a2d621

Deterministic extraction method

No generative model selected, summarized, or transformed the results.

Evidence classified preserved repository files, parsed bounded structured tables, inferred column types, and selected registered components using versioned rules.

Data and provenance

Immutable publication and repository sources.

Reuse boundary

Only released and preserved source rows are displayed.

No model is rerun and no missing value is inferred.

Pinned scientific commit: bf6ac86b961d575f3524b994dcce9fff993637be

Limitations

Deterministic coverage boundaries.

Every accepted released table cell is represented by registered Evidence components; unstructured claims are not converted into numerical results.

Citation

Cite the scholarly record and pinned analysis source.

Scholarly publication

Si Li, Yanyan Huang. Sequence-audited comparative genomics of genome-maintenance genes in vertebrate lifespan evolution. 10.5281/zenodo.20798437.

Open publication

Pinned analysis source

https://github.com/jackeikee-debug/nature-bird-lifespan, commit bf6ac86b961d575f3524b994dcce9fff993637be.

Open pinned source