Study

Sequence-audited comparative genomics of genome-maintenance genes in vertebrate lifespan evolution

Processed data and frozen outputs supporting the manuscript “Sequence-audited comparative genomics of genome-maintenance genes in vertebrate lifespan evolution.” The archive includes source data for four main figures, 41 supplementary data tables, a dated species tree, protein alignments, gene-family trees, a reproducibility guide, and SHA-256 checksums.

Abstract

Processed data and frozen outputs supporting the manuscript “Sequence-audited comparative genomics of genome-maintenance genes in vertebrate lifespan evolution.” The archive includes source data for four main figures, 41 supplementary data tables, a dated species tree, protein alignments, gene-family trees, a reproducibility guide, and SHA-256 checksums. Analysis code is available at https://github.com/jackeikee-debug/nature-bird-lifespan, release v1.0.0.

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Result tables50
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Repositories1
Result tables50
Charts37
Released figures18
Source datasets50
Complete tables50

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The preserved source contains 50 result tables; 50 have complete deterministic representation coverage.

Figure 4 Samhd1 Robustness source data

36 materialized released rows from submission:submission-0874a5a043ddb0a424e0af00:1/nature-bird-lifespan-data-v1.0.0.zip!/Source_Data/Figure_4_samhd1_robustness.tsv.

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Figure 4 Samhd1 Robustness source data

36 materialized released rows from submission:submission-0874a5a043ddb0a424e0af00:1/nature-bird-lifespan-data-v1.0.0.zip!/Source_Data/Figure_4_samhd1_robustness.tsv.

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ScopePredictorNPredictor CenterPredictor ScaleLambdaLambda MethodEstimate Per SdSeConf LowConf HighTPFit NoteErrorQ Within Scope
all_speciesdomain_minus_nondomain_product53-0.01191652230909690.05171638121281691e-06maximum_likelihood0.1279860905030070.02965045316279030.06987120230393790.1861009787020764.316496945268367.30353793771954e-050.000292141517508782
all_speciesdomain_identity_coverage_product530.6692307692307690.1141950514955530.727825239872756maximum_likelihood0.2083955002736070.06598635487261190.07906224472328770.3377287558239263.158160511759120.002667262014046210.00533452402809242
all_specieswhole_protein_identity_coverage_product530.6786726143830250.09357584660841880.800123445303648maximum_likelihood0.1187366964412110.0832977769510362-0.04452694638282050.2820003392652411.425448562823060.1601195143571240.213492685809499
all_speciesnondomain_identity_coverage_product530.6811472915398660.09049321943176020.752850591156449maximum_likelihood0.05068557141266850.0787205937438783-0.1036067923253330.204977935150670.6438667317166930.5225469909223190.522546990922319
birds_onlydomain_minus_nondomain_product20-0.04608405707196030.05054308398284661e-06maximum_likelihood0.132459542831790.04685487971432610.04062397859171120.2242951070718692.827017028736290.01117019117623120.0341861238179484
birds_onlydomain_identity_coverage_product200.5461538461538460.05467835794699311e-06maximum_likelihood0.1257609476589760.04786934928366620.03193702306299040.2195848722549622.627170612112080.01709306190897420.0341861238179484
birds_onlywhole_protein_identity_coverage_product200.5826677316293930.01901368204503441e-06maximum_likelihood0.08266713775557870.0528249244086471-0.02086971408536960.1862039895965271.564926759119920.1350108042220920.180014405629456
birds_onlynondomain_identity_coverage_product200.5922379032258060.01425430916731291e-06maximum_likelihood0.01273223814909170.0562238965250045-0.09746659903991710.12293107533810.2264559899975850.8233985087115250.823398508711525
domain_coverage_ge_0.8domain_minus_nondomain_product48-0.001082376964433430.04017898778577581e-06maximum_likelihood0.1087430044837510.02944753406204170.05102583772214930.1664601712453533.692771158856470.0005870606821825050.00234824272873002
domain_coverage_ge_0.8domain_identity_coverage_product480.6899038461538460.09848603738277040.757028581747695maximum_likelihood0.1573941494994010.0683749267895290.02337929299192460.2914090060068782.301927868733090.02591712195404660.0518342439080932
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Figure 4 Samhd1 Species source data

680 materialized released rows from submission:submission-0874a5a043ddb0a424e0af00:1/nature-bird-lifespan-data-v1.0.0.zip!/Source_Data/Figure_4_samhd1_species.tsv.

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Figure 4 Samhd1 Species source data

680 materialized released rows from submission:submission-0874a5a043ddb0a424e0af00:1/nature-bird-lifespan-data-v1.0.0.zip!/Source_Data/Figure_4_samhd1_species.tsv.

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Scientific NameOpentree Tip LabelCladeFlight StatusHuman Gene SymbolAlignment Record IdSelected AccessionSequence SourceSequence AvailablePfam Domain InstancesPfam Domain SignaturesHuman Domain Reference ResiduesHuman Nondomain Reference ResiduesDomain Reference CoverageDomain Aligned IdentityDomain Identity Coverage ProductNondomain Reference CoverageNondomain Aligned IdentityNondomain Identity Coverage ProductDomain Minus Nondomain Identity
Agelaius phoeniceusAvesflightedDNMT1S001XP_077048462.1ncbi_gene_longest_isoformTrue6510156170.99507389162561580.84851485148514850.84433497536945810.77471636952998380.62970711297071120.48784440842787680.21880773851443724
Ailuropoda melanoleucaMammalia_nonChiropteranon_flyingDNMT1S002XP_011225961.3ncbi_gene_longest_isoformTrue6510156171.00.95566502463054190.95566502463054190.96920583468395460.84615384615384610.8200972447325770.10951117847669578
Alectura lathamiAvesflightedDNMT1S003NXL95466.1strict_gff_sequenceTrue6510156170.65911330049261090.82660687593423020.54482758620689650.72285251215559150.66143497757847540.478119935170178260.16517189835575485
Alligator mississippiensisReptilianon_flyingDNMT1S004XP_059588198.1ncbi_gene_longest_isoformTrue6510156170.98325123152709360.84068136272545090.82660098522167490.77633711507293360.63883089770354910.49594813614262560.20185046502190185
Alligator sinensisReptilianon_flyingDNMT1S005XP_025059761.1ncbi_gene_longest_isoformTrue6510156170.99802955665024630.83909180651530110.83743842364532020.78444084278768230.6404958677685950.50243111831442470.1985959387467061
Ammodramus caudacutusAvesflightedDNMT1S006XP_058677345.1ncbi_gene_longest_isoformTrue6510156170.99507389162561580.85049504950495050.84630541871921180.78768233387358190.60699588477366250.478119935170178260.24349916473128796
Anas platyrhynchosAvesflightedDNMT1False651015617
Anolis carolinensisReptilianon_flyingDNMT1S008XP_008117963.2ncbi_gene_longest_isoformTrue6510156170.99507389162561580.83069306930693070.82660098522167480.77471636952998380.62133891213389130.48136142625607780.2093541571730394
Anseranas semipalmataAvesflightedDNMT1S009NXI71866.1strict_gff_sequenceTrue6510156170.65714285714285710.83208395802098960.54679802955665020.72285251215559150.66143497757847540.478119935170178260.1706489804425142
Antrozous pallidusMammalia_Chiropterapowered_flightDNMT1False651015617
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Figure Source Data Map source data

12 materialized released rows from submission:submission-0874a5a043ddb0a424e0af00:1/nature-bird-lifespan-data-v1.0.0.zip!/Source_Data/Figure_source_data_map.tsv.

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Figure Source Data Map source data

12 materialized released rows from submission:submission-0874a5a043ddb0a424e0af00:1/nature-bird-lifespan-data-v1.0.0.zip!/Source_Data/Figure_source_data_map.tsv.

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FigureSource Data Files
Figure 1Source_Data/Figure_1_design_counts.tsv
Figure 2Source_Data/Figure_2_module_ranking.tsv; Supplementary_Data/Supplementary_Data_2_final_module_models.tsv
Figure 3Source_Data/Figure_3_evidence_waterfall.tsv; Source_Data/Figure_3_evidence_by_gene.tsv
Figure 4Source_Data/Figure_4_samhd1_species.tsv; Source_Data/Figure_4_samhd1_robustness.tsv; Source_Data/Figure_4_samhd1_leave_one_species.tsv
Supplementary Figure 1Supplementary_Data/Supplementary_Data_1_species_traits.tsv; Supplementary_Data/Supplementary_Data_13_datelife_node_calibration_audit.tsv; Supplementary_Data/Supplementary_Data_14_datelife_species_coverage.tsv
Supplementary Figure 2Supplementary_Data/Supplementary_Data_6_branch_length_sensitivity.tsv
Supplementary Figure 3Supplementary_Data/Supplementary_Data_41_sequence_validation_model_impact.tsv
Supplementary Figure 4a-dSupplementary_Data/Supplementary_Data_4_gene_tree_summary.tsv; Supplementary_Data/Supplementary_Data_5_trimmed_alignment_qc.tsv; Supplementary_Data/Gene_Trees/
Supplementary Figure 4e-hSupplementary_Data/Supplementary_Data_4_gene_tree_summary.tsv; Supplementary_Data/Gene_Trees/
Supplementary Figure 5Supplementary_Data/Supplementary_Data_11_species_influence_pgls.tsv
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Supplementary Data 1 Species Traits source data

233 materialized released rows from submission:submission-0874a5a043ddb0a424e0af00:1/nature-bird-lifespan-data-v1.0.0.zip!/Supplementary_Data/Supplementary_Data_1_species_traits.tsv.

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Supplementary Data 1 Species Traits source data

233 materialized released rows from submission:submission-0874a5a043ddb0a424e0af00:1/nature-bird-lifespan-data-v1.0.0.zip!/Supplementary_Data/Supplementary_Data_1_species_traits.tsv.

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Scientific NameTree LabelTree Search NameName RankCladeFlight StatusSource HintAnage OrderAnage FamilyCommon NameBody Mass GMax Lifespan YearsSexual Maturity YearsLifespan Residual Log10Lifespan Residual RatioData QualitySample SizeSpecimen OriginRisk FlagsOtt Id
Acanthagenys rufogularisAcanthagenys_rufogularisAcanthagenys rufogularisbinomialAvesflightedBirdTree_or_OpenTreePasseriformesMeliphagidaeSpiny-cheeked honeyeater47.813.60.0462171.112288acceptablemediumwildmissing_sexual_maturity927350
Acanthis flammeaAcanthis_flammeaAcanthis flammeabinomialAvesflightedBirdTree_or_OpenTreePasseriformesFringillidaeCommon redpoll1412.20.9993160.0709581.177491acceptablemediumwildnone38566
Acanthiza chrysorrhoaAcanthiza_chrysorrhoaAcanthiza chrysorrhoabinomialAvesflightedBirdTree_or_OpenTreePasseriformesAcanthizidaeYellow-rumped thornbill9.37513.10.1253561.334614acceptablelargewildmissing_sexual_maturity808269
Accipiter cooperiiAccipiter_cooperiiAccipiter cooperiibinomialAvesflightedBirdTree_or_OpenTreeAccipitriformesAccipitridaeCooper's hawk526.6420.31.998630.0796411.201272acceptablemediumwildnone764598
Acrocephalus arundinaceusAcrocephalus_arundinaceusAcrocephalus arundinaceusbinomialAvesflightedBirdTree_or_OpenTreePasseriformesAcrocephalidaeGreat reed-warbler21.910.10.999316-0.0372860.917729acceptablemediumwildnone800677
Actitis hypoleucosActitis_hypoleucosActitis hypoleucosbinomialAvesflightedBirdTree_or_OpenTreeCharadriiformesScolopacidaeCommon sandpiper4814.50.9993160.0738021.185228acceptablemediumwildnone792983
Aegithalos caudatusAegithalos_caudatusAegithalos caudatusbinomialAvesflightedBirdTree_or_OpenTreePasseriformesAegithalidaeLong-tailed tit8.911.10.9993160.0564531.138813acceptablemediumwildnone467867
Aegotheles cristatusAegotheles_cristatusAegotheles cristatusbinomialAvesflightedBirdTree_or_OpenTreeApodiformesAegothelidaeAustralian owlet-nightjar44.1255.9-0.3117840.487771acceptablesmallwildsample_size_small;missing_sexual_maturity540033
Aerodramus terraereginaeAerodramus_terraereginaeAerodramus terraereginaebinomialAvesflightedBirdTree_or_OpenTreeApodiformesApodidaeAustralian swiftlet11.8759.3-0.0372780.917746acceptablemediumwildmissing_sexual_maturity423342
Aethia cristatellaAethia_cristatellaAethia cristatellabinomialAvesflightedBirdTree_or_OpenTreeCharadriiformesAlcidaeCrested auklet28910.82.99795-0.1592850.692971acceptablemediumwildnone855480
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Supplementary Data 10 Clade Sensitivity Models source data

138 materialized released rows from submission:submission-0874a5a043ddb0a424e0af00:1/nature-bird-lifespan-data-v1.0.0.zip!/Supplementary_Data/Supplementary_Data_10_clade_sensitivity_models.tsv.

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Supplementary Data 10 Clade Sensitivity Models source data

138 materialized released rows from submission:submission-0874a5a043ddb0a424e0af00:1/nature-bird-lifespan-data-v1.0.0.zip!/Supplementary_Data/Supplementary_Data_10_clade_sensitivity_models.tsv.

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Score VariantSubsetMaintenance ModuleScore ColModelFormulaNClade CountLambdaEstimateSeTPErrorP Bh By Subset ModelRank By P
full_background_sensitivityall_primarycancer_surveillance_senescencecancer_surveillance_senescence_scoremass_clade_modulelog10_max_lifespan_years ~ log10_body_mass_g + clade + cancer_surveillance_senescence_score6841e-060.319729105706280.1031327496698753.100170476688760.002908118111765830.006114498280734181
full_background_sensitivityall_primarytransposon_repeat_suppressiontransposon_repeat_suppression_scoremass_clade_modulelog10_max_lifespan_years ~ log10_body_mass_g + clade + transposon_repeat_suppression_score6841e-060.2860945023252020.09357229520568993.057470180637460.003292295763784650.006114498280734182
full_background_sensitivityall_primaryinflammation_innate_immune_restraintinflammation_innate_immune_restraint_scoremass_clade_modulelog10_max_lifespan_years ~ log10_body_mass_g + clade + inflammation_innate_immune_restraint_score6841e-060.3375277679086660.1120039514096163.013534466067830.003736631895296490.006114498280734183
full_background_sensitivityall_primarychromatin_repression_heterochromatinchromatin_repression_heterochromatin_scoremass_clade_modulelog10_max_lifespan_years ~ log10_body_mass_g + clade + chromatin_repression_heterochromatin_score6841e-060.2627768743617020.08813771809143512.981434963962810.004095896165125180.006114498280734184
full_background_sensitivityall_primaryDNA_repair_replication_stressDNA_repair_replication_stress_scoremass_clade_modulelog10_max_lifespan_years ~ log10_body_mass_g + clade + DNA_repair_replication_stress_score6841e-060.2980788813901720.1034394979889872.881673704776760.00542761224688770.006114498280734185
full_background_sensitivityall_primaryproteostasis_autophagy_mitophagyproteostasis_autophagy_mitophagy_scoremass_clade_modulelog10_max_lifespan_years ~ log10_body_mass_g + clade + proteostasis_autophagy_mitophagy_score6841e-060.3130348575067320.1102696886549932.838811475074910.006114498280734180.006114498280734186
full_background_sensitivityall_primarytransposon_repeat_suppressiontransposon_repeat_suppression_scoremass_modulelog10_max_lifespan_years ~ log10_body_mass_g + transposon_repeat_suppression_score6840.5004674540304310.31810003380780.08697792970283193.657250004623220.0005120378258287590.001019100350704521
full_background_sensitivityall_primaryinflammation_innate_immune_restraintinflammation_innate_immune_restraint_scoremass_modulelog10_max_lifespan_years ~ log10_body_mass_g + inflammation_innate_immune_restraint_score6840.4598694889494960.3690959385696830.1034548166984693.56770182721850.000682424614853350.001019100350704522
full_background_sensitivityall_primarychromatin_repression_heterochromatinchromatin_repression_heterochromatin_scoremass_modulelog10_max_lifespan_years ~ log10_body_mass_g + chromatin_repression_heterochromatin_score6840.4696836165751130.2906982604745630.08210321706988893.540643970468430.0007437224225390620.001019100350704523
full_background_sensitivityall_primaryDNA_repair_replication_stressDNA_repair_replication_stress_scoremass_modulelog10_max_lifespan_years ~ log10_body_mass_g + DNA_repair_replication_stress_score6840.4796553141384050.3339664201810330.09600434014690053.47865960715960.0009044460287295220.001019100350704524
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Supplementary Data 11 Species Influence Pgls source data

136 materialized released rows from submission:submission-0874a5a043ddb0a424e0af00:1/nature-bird-lifespan-data-v1.0.0.zip!/Supplementary_Data/Supplementary_Data_11_species_influence_pgls.tsv.

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Supplementary Data 11 Species Influence Pgls source data

136 materialized released rows from submission:submission-0874a5a043ddb0a424e0af00:1/nature-bird-lifespan-data-v1.0.0.zip!/Supplementary_Data/Supplementary_Data_11_species_influence_pgls.tsv.

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ModelOmitted Tip LabelScientific NameCladeBaseline NBaseline EstimateBaseline SeBaseline PBaseline LambdaLoo NLoo EstimateLoo SeLoo PLoo LambdaLoo Conf LowLoo Conf HighDelta EstimateStandardized Estimate ShiftInfluence ThresholdHigh Influence
mass_clade_modulePedionomus_torquatus_ott163953Pedionomus torquatusAves680.2906839971181680.08571703687890780.001215875452507120.626857702177159670.2325865825686210.07659383638436350.003516541131792120.7194356827327590.08246266325526890.382710501881974-0.0580974145495468-0.6777814150484550.242535625036333TRUE
mass_clade_moduleInia_geoffrensis_ott698411Inia geoffrensisMammalia_nonChiroptera680.2906839971181680.08571703687890780.001215875452507120.626857702177159670.3209831068883490.08845991267802080.0005840744315395160.7031013226683030.1476016780394280.494364535737270.03029910977018080.3534782684215310.242535625036333TRUE
mass_clade_moduleAquila_chrysaetos_ott263127Aquila chrysaetosAves680.2906839971181680.08571703687890780.001215875452507120.626857702177159670.2718604197542650.08600695648959920.002449179084912820.6282545394846460.1032867850346510.440434054473879-0.0188235773639031-0.2196013540516460.242535625036333FALSE
mass_clade_moduleMyotis_brandtii_ott353460Myotis brandtiiMammalia_Chiroptera680.2906839971181680.08571703687890780.001215875452507120.626857702177159670.2723087010526980.08287030726598230.001687717349832860.7211795858492550.1098828988113730.434734503294024-0.0183752960654697-0.2143715734297780.242535625036333FALSE
mass_clade_moduleAnseranas_semipalmata_ott714464Anseranas semipalmataAves680.2906839971181680.08571703687890780.001215875452507120.626857702177159670.3082228902608420.0873402779151950.000799820497457970.6130581967048580.137035945547060.4794098349746250.01753889314267430.2046138525232910.242535625036333FALSE
mass_clade_moduleSaccopteryx_bilineata_ott190912Saccopteryx bilineataMammalia_Chiroptera680.2906839971181680.08571703687890780.001215875452507120.626857702177159670.3078821175069870.08087314652552870.0003287696666776090.6427456871137250.1493707503169510.4663934846970240.01719812038881940.2006382979980410.242535625036333FALSE
mass_clade_moduleCinclus_cinclus_ott496009Cinclus cinclusAves680.2906839971181680.08571703687890780.001215875452507120.626857702177159670.3073330822178480.08709411253785580.0008004275940058920.6226325356974020.136628621643650.4780375427920450.01664908509967980.1942330918788050.242535625036333FALSE
mass_clade_moduleLeiothrix_lutea_ott965458Leiothrix luteaAves680.2906839971181680.08571703687890780.001215875452507120.626857702177159670.3067182540236460.08571414008113550.0006847423314280120.6669798432016430.138718539464620.4747179685826710.01603425690547770.1870603265034610.242535625036333FALSE
mass_clade_moduleTodus_mexicanus_ott741575Todus mexicanusAves680.2906839971181680.08571703687890780.001215875452507120.626857702177159670.3061557634894080.08647649395949820.0007718650304637810.6120180333465890.1366618353287910.4756496916500240.01547176637123960.1804981475630860.242535625036333FALSE
mass_clade_moduleAmmodramus_caudacutus_ott567252Ammodramus caudacutusAves680.2906839971181680.08571703687890780.001215875452507120.626857702177159670.3052200166697970.08743338652452750.0009009141533655730.6154659349026980.1338505790817230.4765894542578710.01453601955162920.1695814517266180.242535625036333FALSE
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Reuse boundary

Only released and preserved source rows are displayed.

No model is rerun and no missing value is inferred.

Pinned scientific commit: bf6ac86b961d575f3524b994dcce9fff993637be

Limitations

Deterministic coverage boundaries.

Every accepted released table cell is represented by registered Evidence components; unstructured claims are not converted into numerical results.

Citation

Cite the scholarly record and pinned analysis source.

Scholarly publication

Si Li, Yanyan Huang. Sequence-audited comparative genomics of genome-maintenance genes in vertebrate lifespan evolution. 10.5281/zenodo.20798437.

Open publication

Pinned analysis source

https://github.com/jackeikee-debug/nature-bird-lifespan, commit bf6ac86b961d575f3524b994dcce9fff993637be.

Open pinned source