Study

Sequence-audited comparative genomics of genome-maintenance genes in vertebrate lifespan evolution

Processed data and frozen outputs supporting the manuscript “Sequence-audited comparative genomics of genome-maintenance genes in vertebrate lifespan evolution.” The archive includes source data for four main figures, 41 supplementary data tables, a dated species tree, protein alignments, gene-family trees, a reproducibility guide, and SHA-256 checksums.

Abstract

Processed data and frozen outputs supporting the manuscript “Sequence-audited comparative genomics of genome-maintenance genes in vertebrate lifespan evolution.” The archive includes source data for four main figures, 41 supplementary data tables, a dated species tree, protein alignments, gene-family trees, a reproducibility guide, and SHA-256 checksums. Analysis code is available at https://github.com/jackeikee-debug/nature-bird-lifespan, release v1.0.0.

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Scientific commitbf6ac86b961d
Result tables50
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LicenseCreative Commons Attribution 4.0 International

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Deterministically extracted immutable study materials.

Repositories1
Result tables50
Charts37
Released figures18
Source datasets50
Complete tables50

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Authoritative metadata and released result artifacts.

The preserved source contains 50 result tables; 50 have complete deterministic representation coverage.

Supplementary Data 12 Pgls Residual Diagnostics source data

68 materialized released rows from submission:submission-0874a5a043ddb0a424e0af00:1/nature-bird-lifespan-data-v1.0.0.zip!/Supplementary_Data/Supplementary_Data_12_pgls_residual_diagnostics.tsv.

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Supplementary Data 12 Pgls Residual Diagnostics source data

68 materialized released rows from submission:submission-0874a5a043ddb0a424e0af00:1/nature-bird-lifespan-data-v1.0.0.zip!/Supplementary_Data/Supplementary_Data_12_pgls_residual_diagnostics.tsv.

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Opentree Tip LabelScientific NameCladeGenome Analysis TierTransposon Repeat Suppression ScoreTransposon Repeat Suppression CoverageFitted Log10 LifespanRaw ResidualStandardized ResidualGeneralized LeverageCook Distance Gls ApproxLeverage ThresholdCook ThresholdHigh LeverageHigh CookLarge Standardized Residual
Candoia_aspera_ott1021991Candoia asperaReptiliatier1_refseq_annotated_chromosome0.8064516129032260.9677419354838711.42476541359223-0.429130218994682-1.801322445773510.1932941484271040.1295791630932460.1764705882352940.0588235294117647TRUETRUEFALSE
Anolis_carolinensis_ott705356Anolis carolinensisReptiliatier1_refseq_annotated_chromosome0.8064516129032260.9677419354838711.19768212375131-0.340349627320042-1.47935832003150.2476434026135080.120060054371230.1764705882352940.0588235294117647TRUETRUEFALSE
Saccopteryx_bilineata_ott190912Saccopteryx bilineataMammalia_Chiropteratier1_refseq_annotated_chromosome0.83225806451612911.27950865904866-0.501357408665021-2.003108939486280.1095579361489740.08228033717739010.1764705882352940.0588235294117647FALSETRUETRUE
Pedionomus_torquatus_ott163953Pedionomus torquatusAvestier2_annotated0.0645161290322580.0645161290322580.966037536410558-0.604309700392965-2.365064691275940.07198923469039250.07231848855671410.1764705882352940.0588235294117647FALSETRUETRUE
Chrysemys_picta_ott587300Chrysemys picta belliiReptiliatier1_refseq_annotated_chromosome0.81290322580645211.428475522341650.3568543126691141.454431773219320.144312625058020.05945996632081230.1764705882352940.0588235294117647FALSETRUEFALSE
Alligator_mississippiensis_ott335590Alligator mississippiensisReptiliatier1_refseq_annotated_chromosome0.82258064516129111.475888260032170.4106024651403081.622705655085710.08991168684085710.04335716299323080.1764705882352940.0588235294117647FALSEFALSEFALSE
Heterocephalus_glaber_ott1048195Heterocephalus glaberMammalia_nonChiropteratier2_annotated0.82258064516129111.227082903419310.264278790414961.096623285135210.1744761474567510.04236138131104820.1764705882352940.0588235294117647FALSEFALSEFALSE
Myotis_brandtii_ott353460Myotis brandtiiMammalia_Chiropteratier2_annotated0.83225806451612911.274645043016490.3381388137032451.328465987813070.07910714882093660.02526715006098980.1764705882352940.0588235294117647FALSEFALSEFALSE
Dromaius_novaehollandiae_ott829513Dromaius novaehollandiaeAvestier1_refseq_annotated_chromosome0.777419354838710.9677419354838711.4587924756273-0.23868438758725-0.9641598310154610.1288962379101670.02292541308494180.1764705882352940.0588235294117647FALSEFALSEFALSE
Anseranas_semipalmata_ott714464Anseranas semipalmataAvestier2_annotated0.09677419354838710.09677419354838711.129090116775950.2653615640502641.056440625685130.1031789757856530.02140052209767960.1764705882352940.0588235294117647FALSEFALSEFALSE
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Supplementary Data 13 Datelife Node Calibration Audit source data

67 materialized released rows from submission:submission-0874a5a043ddb0a424e0af00:1/nature-bird-lifespan-data-v1.0.0.zip!/Supplementary_Data/Supplementary_Data_13_datelife_node_calibration_audit.tsv.

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Supplementary Data 13 Datelife Node Calibration Audit source data

67 materialized released rows from submission:submission-0874a5a043ddb0a424e0af00:1/nature-bird-lifespan-data-v1.0.0.zip!/Supplementary_Data/Supplementary_Data_13_datelife_node_calibration_audit.tsv.

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NodeDescendant Tip CountChild CountRaw Median Age MaRaw Q25 Age MaRaw Q75 Age MaSource Tree CountSource Tree IdsGrafen Fallback Age MaFinal Age MaAge MethodAbsolute Adjustment Ma
69682323.99999875318.999999375324.249998375334;188;262323.99999875323.99999875datelife_median0
70292166.2166.2168.2535;36;37;188;258135.402984552239166.2datelife_median0
7128298.795.75103.675435;36;37;258130.56716367537398.7datelife_median0
7226296.791.1727598.55635;36;37;188;257;258120.89552192164296.7datelife_median0
732294.593.695.55335;36;374.8358208768657494.5datelife_median0
7424289.2587.3590.625635;36;37;56;57;58111.2238801679189.25datelife_median0
7520288.787.889.8335;36;3791.880596660447888.7datelife_median0
769272.5569.129858464330874.875435;36;37;14638.686567014925472.55datelife_median0
778252.235.97237861237952.2535;36;37;146;17633.850746138059752.2datelife_median0
78624933.975836824326951.9535;36;37;146;17624.179104384328449datelife_median0
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Supplementary Data 14 Datelife Species Coverage source data

68 materialized released rows from submission:submission-0874a5a043ddb0a424e0af00:1/nature-bird-lifespan-data-v1.0.0.zip!/Supplementary_Data/Supplementary_Data_14_datelife_species_coverage.tsv.

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Supplementary Data 14 Datelife Species Coverage source data

68 materialized released rows from submission:submission-0874a5a043ddb0a424e0af00:1/nature-bird-lifespan-data-v1.0.0.zip!/Supplementary_Data/Supplementary_Data_14_datelife_species_coverage.tsv.

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Opentree Tip LabelScientific NameDatelife Exact Tip Match
Heterocephalus_glaber_ott1048195Heterocephalus glaberTRUE
Macaca_mulatta_ott689650Macaca mulattaTRUE
Lipotes_vexillifer_ott5269Lipotes vexilliferTRUE
Inia_geoffrensis_ott698411Inia geoffrensisTRUE
Delphinus_delphis_ott698438Delphinus delphisTRUE
Delphinapterus_leucas_ott851318Delphinapterus leucasTRUE
Physeter_catodon_ott276851Physeter catodonTRUE
Kogia_breviceps_ott825964Kogia brevicepsTRUE
Balaenoptera_acutorostrata_ott800317Balaenoptera acutorostrataTRUE
Eschrichtius_robustus_ott800320Eschrichtius robustusTRUE
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Supplementary Data 15 Targeted Protein Conservation Rows source data

680 materialized released rows from submission:submission-0874a5a043ddb0a424e0af00:1/nature-bird-lifespan-data-v1.0.0.zip!/Supplementary_Data/Supplementary_Data_15_targeted_protein_conservation_rows.tsv.

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Supplementary Data 15 Targeted Protein Conservation Rows source data

680 materialized released rows from submission:submission-0874a5a043ddb0a424e0af00:1/nature-bird-lifespan-data-v1.0.0.zip!/Supplementary_Data/Supplementary_Data_15_targeted_protein_conservation_rows.tsv.

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Scientific NameOpentree Tip LabelCladeFlight StatusHuman Gene SymbolAlignment Record IdOrtholog Gene IdOrtholog StatusOrtholog ConfidenceSequence AvailableSequence SourceSelected AccessionProtein LengthHuman Reference AccessionHuman Reference LengthProtein Length RatioLength CompletenessHuman Reference CoverageAligned IdentityIdentity Coverage Product
Agelaius phoeniceusAvesflightedDNMT1S001129133971exact_symbolmediumTruencbi_gene_longest_isoformXP_077048462.11514.0NP_001124295.116320.92769607843137260.92769607843137260.91176470588235290.77822580645161290.7095588235294117
Ailuropoda melanoleucaMammalia_nonChiropteranon_flyingDNMT1S002100476727exact_symbolmediumTruencbi_gene_longest_isoformXP_011225961.31622.0NP_001124295.116320.99387254901960790.99387254901960790.98835784313725490.91506509609423440.9044117647058824
Alectura lathamiAvesflightedDNMT1S003sequence_validation_gff_sequence_supportedhighTruestrict_gff_sequenceNXL95466.11137.0NP_001124295.116320.69669117647058820.69669117647058820.68321078431372550.76053811659192830.5196078431372549
Alligator mississippiensisReptilianon_flyingDNMT1S004102570528exact_symbolmediumTruencbi_gene_longest_isoformXP_059588198.11527.0NP_001124295.116320.93566176470588240.93566176470588240.90502450980392160.77522004062288420.7015931372549019
Alligator sinensisReptilianon_flyingDNMT1S005102381893exact_symbolmediumTruencbi_gene_longest_isoformXP_025059761.11555.0NP_001124295.116320.95281862745098030.95281862745098030.91727941176470580.77488309953239810.7107843137254901
Ammodramus caudacutusAvesflightedDNMT1S006131569139exact_symbolmediumTruencbi_gene_longest_isoformXP_058677345.11527.0NP_001124295.116320.93566176470588240.93566176470588240.91666666666666660.77139037433155080.7071078431372548
Anas platyrhynchosAvesflightedDNMT1101799147exact_symbolmediumFalseNP_001124295.11632
Anolis carolinensisReptilianon_flyingDNMT1S008100565926exact_symbolmediumTruencbi_gene_longest_isoformXP_008117963.21524.0NP_001124295.116320.93382352941176470.93382352941176470.91176470588235290.76344086021505380.696078431372549
Anseranas semipalmataAvesflightedDNMT1S009sequence_validation_gff_sequence_supportedhighTruestrict_gff_sequenceNXI71866.11137.0NP_001124295.116320.69669117647058820.69669117647058820.68198529411764710.76370170709793350.5208333333333334
Antrozous pallidusMammalia_Chiropterapowered_flightDNMT1no_symbol_taxid_candidateFalseNP_001124295.11632
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Supplementary Data 16 Targeted Protein Conservation Species source data

68 materialized released rows from submission:submission-0874a5a043ddb0a424e0af00:1/nature-bird-lifespan-data-v1.0.0.zip!/Supplementary_Data/Supplementary_Data_16_targeted_protein_conservation_species.tsv.

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Supplementary Data 16 Targeted Protein Conservation Species source data

68 materialized released rows from submission:submission-0874a5a043ddb0a424e0af00:1/nature-bird-lifespan-data-v1.0.0.zip!/Supplementary_Data/Supplementary_Data_16_targeted_protein_conservation_species.tsv.

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Scientific NameCladeFlight StatusFocal Genes TotalFocal Sequences NFocal Sequence FractionQualified Sequences NAggregate Identity Gene ZAggregate Identity Gene Clade ZMean Identity Coverage ProductMean Length CompletenessOpentree Tip LabelBody Mass GLog10 Body Mass GMax Lifespan YearsPgls Model C Mass Clade ResidualGenome Analysis Tier
Agelaius phoeniceusAvesflighted1090.99-0.5874083004497260.2592933285718410.6835578052257210.929266364250032Agelaius_phoeniceus_ott22660556.71.75358305889291200.246198779383737tier1_refseq_annotated_chromosome
Ailuropoda melanoleucaMammalia_nonChiropteranon_flying10101100.699131847517896-0.08611393024022190.8381023538809270.916066720971053Ailuropoda_melanoleuca_ott8725731175005.0700378666077636.80.0700459324566742tier1_refseq_annotated_chromosome
Alectura lathamiAvesflighted1050.55-1.24253119304713-0.6832653857928730.6513304633552030.850259748023393Alectura_lathami_ott57095623403.3692158574101412.5-0.234108582567407tier2_annotated
Alligator mississippiensisReptilianon_flying1010110-0.467694628911614-0.06107241528570450.6916256108921130.943272369776501Alligator_mississippiensis_ott33559010793.03302144468291770.497971433424552tier1_refseq_annotated_chromosome
Alligator sinensisReptilianon_flying1010110-0.954111411000359-0.8035842485651050.6371955589296780.839064807228677Alligator_sinensis_ott953151146004.16435285578444650.230996494708646tier2_annotated
Ammodramus caudacutusAvesflighted1010110-0.6542137087521280.09641188497648230.6706685601522050.901020472722182Ammodramus_caudacutus_ott56725216.51.21748394421391100.0368132524762498tier1_refseq_annotated_chromosome
Anas platyrhynchosAvesflighted1090.99-0.5329803332693460.5562176007542280.6830454971366610.894132192887503Anas_platyrhynchos_ott76516710203.0086001717619229.10.194520518225029tier1_refseq_annotated_chromosome
Anolis carolinensisReptilianon_flying1010110-0.67795448086173-0.644080196471050.670391627903690.905620115999022Anolis_carolinensis_ott7053562.4550.3900514964589877.2-0.0793793399184356tier1_refseq_annotated_chromosome
Anseranas semipalmataAvesflighted1040.44-1.29824108002778-0.667661153822810.6505341519653670.82792296246641Anseranas_semipalmata_ott71446420713.3161800988934524.80.0724993824731792tier2_annotated
Antrozous pallidusMammalia_Chiropterapowered_flight10000Antrozous_pallidus_ott913941221.3424226808222114.80.0665069689343958tier2_annotated
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Supplementary Data 17 Targeted Protein Conservation Pgls source data

34 materialized released rows from submission:submission-0874a5a043ddb0a424e0af00:1/nature-bird-lifespan-data-v1.0.0.zip!/Supplementary_Data/Supplementary_Data_17_targeted_protein_conservation_pgls.tsv.

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Supplementary Data 17 Targeted Protein Conservation Pgls source data

34 materialized released rows from submission:submission-0874a5a043ddb0a424e0af00:1/nature-bird-lifespan-data-v1.0.0.zip!/Supplementary_Data/Supplementary_Data_17_targeted_protein_conservation_pgls.tsv.

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Test FamilyScopeHuman Gene SymbolPredictorNLambdaEstimate Per SdSeConf LowConf HighTPErrorQ
gene_level_primaryall_speciesSETDB2identity_coverage_product480.7129944475493170.09616911466801370.0538792517096615-0.009434218682922870.201772448018951.784900710689880.0808725671353780.80872567135378
gene_level_primaryall_speciesMBD3identity_coverage_product550.8330228835007750.05799186790160530.0415312682424256-0.02340941785354890.1393931536567591.396342330869750.1684324246267960.842162123133978
gene_level_primaryall_speciesHELLSidentity_coverage_product570.8320977766037140.04880318947713330.0608272967997978-0.07041831225047040.1680246912047370.8023238257284440.4258189562790790.91922248125033
gene_level_primaryall_speciesMORC3identity_coverage_product500.8314382312066760.03062294010680710.0500817378133582-0.06753726600737490.1287831462209890.6114592153517310.5437808571680980.91922248125033
gene_level_primaryall_speciesMBD2identity_coverage_product410.8056920952621960.03365524094566620.0558749074659218-0.07585957768754050.1431700595788730.6023319316670470.5504394918505890.91922248125033
gene_level_primaryall_speciesDNMT3Bidentity_coverage_product490.7828424880317660.06015488729682110.112961459995143-0.161249574293660.2815593488873020.5325257596653540.5968707144593670.91922248125033
gene_level_primaryall_speciesSAMHD1identity_coverage_product550.7251456716434790.02550437314600810.0547850793008465-0.08187438228365110.1328831285756670.4655350228837590.6434557368752310.91922248125033
gene_level_primaryall_speciesUHRF1identity_coverage_product540.8031909008393480.008217331201110020.0326147417113404-0.05570756255311710.07214222495533710.2519514418920810.8020717556175510.942075673054634
gene_level_primaryall_speciesDNMT3Aidentity_coverage_product500.795632212890666-0.006225473029314190.0332333913250337-0.07136292002638030.0589119739677519-0.1873258425066210.8521947590972450.942075673054634
gene_level_primaryall_speciesDNMT1identity_coverage_product470.786226855269878-0.004125650680776230.056463018701427-0.1147931673355730.106541865974021-0.07306819181228020.9420756730546340.942075673054634
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Evidence classified preserved repository files, parsed bounded structured tables, inferred column types, and selected registered components using versioned rules.

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Pinned scientific commit: bf6ac86b961d575f3524b994dcce9fff993637be

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Scholarly publication

Si Li, Yanyan Huang. Sequence-audited comparative genomics of genome-maintenance genes in vertebrate lifespan evolution. 10.5281/zenodo.20798437.

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https://github.com/jackeikee-debug/nature-bird-lifespan, commit bf6ac86b961d575f3524b994dcce9fff993637be.

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