Study

Sequence-audited comparative genomics of genome-maintenance genes in vertebrate lifespan evolution

Processed data and frozen outputs supporting the manuscript “Sequence-audited comparative genomics of genome-maintenance genes in vertebrate lifespan evolution.” The archive includes source data for four main figures, 41 supplementary data tables, a dated species tree, protein alignments, gene-family trees, a reproducibility guide, and SHA-256 checksums.

Abstract

Processed data and frozen outputs supporting the manuscript “Sequence-audited comparative genomics of genome-maintenance genes in vertebrate lifespan evolution.” The archive includes source data for four main figures, 41 supplementary data tables, a dated species tree, protein alignments, gene-family trees, a reproducibility guide, and SHA-256 checksums. Analysis code is available at https://github.com/jackeikee-debug/nature-bird-lifespan, release v1.0.0.

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Scientific commitbf6ac86b961d
Result tables50
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LicenseCreative Commons Attribution 4.0 International

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Repositories1
Result tables50
Charts37
Released figures18
Source datasets50
Complete tables50

Extracted study record

Authoritative metadata and released result artifacts.

The preserved source contains 50 result tables; 50 have complete deterministic representation coverage.

Supplementary Data 23 Targeted Domain Conservation Rows source data

680 materialized released rows from submission:submission-0874a5a043ddb0a424e0af00:1/nature-bird-lifespan-data-v1.0.0.zip!/Supplementary_Data/Supplementary_Data_23_targeted_domain_conservation_rows.tsv.

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Supplementary Data 23 Targeted Domain Conservation Rows source data

680 materialized released rows from submission:submission-0874a5a043ddb0a424e0af00:1/nature-bird-lifespan-data-v1.0.0.zip!/Supplementary_Data/Supplementary_Data_23_targeted_domain_conservation_rows.tsv.

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Scientific NameOpentree Tip LabelCladeFlight StatusHuman Gene SymbolAlignment Record IdSelected AccessionSequence SourceSequence AvailablePfam Domain InstancesPfam Domain SignaturesHuman Domain Reference ResiduesHuman Nondomain Reference ResiduesDomain Reference CoverageDomain Aligned IdentityDomain Identity Coverage ProductNondomain Reference CoverageNondomain Aligned IdentityNondomain Identity Coverage ProductDomain Minus Nondomain Identity
Agelaius phoeniceusAvesflightedDNMT1S001XP_077048462.1ncbi_gene_longest_isoformTrue6510156170.99507389162561580.84851485148514850.84433497536945810.77471636952998380.62970711297071120.48784440842787680.21880773851443724
Ailuropoda melanoleucaMammalia_nonChiropteranon_flyingDNMT1S002XP_011225961.3ncbi_gene_longest_isoformTrue6510156171.00.95566502463054190.95566502463054190.96920583468395460.84615384615384610.8200972447325770.10951117847669578
Alectura lathamiAvesflightedDNMT1S003NXL95466.1strict_gff_sequenceTrue6510156170.65911330049261090.82660687593423020.54482758620689650.72285251215559150.66143497757847540.478119935170178260.16517189835575485
Alligator mississippiensisReptilianon_flyingDNMT1S004XP_059588198.1ncbi_gene_longest_isoformTrue6510156170.98325123152709360.84068136272545090.82660098522167490.77633711507293360.63883089770354910.49594813614262560.20185046502190185
Alligator sinensisReptilianon_flyingDNMT1S005XP_025059761.1ncbi_gene_longest_isoformTrue6510156170.99802955665024630.83909180651530110.83743842364532020.78444084278768230.6404958677685950.50243111831442470.1985959387467061
Ammodramus caudacutusAvesflightedDNMT1S006XP_058677345.1ncbi_gene_longest_isoformTrue6510156170.99507389162561580.85049504950495050.84630541871921180.78768233387358190.60699588477366250.478119935170178260.24349916473128796
Anas platyrhynchosAvesflightedDNMT1False651015617
Anolis carolinensisReptilianon_flyingDNMT1S008XP_008117963.2ncbi_gene_longest_isoformTrue6510156170.99507389162561580.83069306930693070.82660098522167480.77471636952998380.62133891213389130.48136142625607780.2093541571730394
Anseranas semipalmataAvesflightedDNMT1S009NXI71866.1strict_gff_sequenceTrue6510156170.65714285714285710.83208395802098960.54679802955665020.72285251215559150.66143497757847540.478119935170178260.1706489804425142
Antrozous pallidusMammalia_Chiropterapowered_flightDNMT1False651015617
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Supplementary Data 24 Targeted Domain Conservation Intervals source data

1803 materialized released rows from submission:submission-0874a5a043ddb0a424e0af00:1/nature-bird-lifespan-data-v1.0.0.zip!/Supplementary_Data/Supplementary_Data_24_targeted_domain_conservation_intervals.tsv.

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Supplementary Data 24 Targeted Domain Conservation Intervals source data

1803 materialized released rows from submission:submission-0874a5a043ddb0a424e0af00:1/nature-bird-lifespan-data-v1.0.0.zip!/Supplementary_Data/Supplementary_Data_24_targeted_domain_conservation_intervals.tsv.

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Scientific NameCladeHuman Gene SymbolSelected AccessionSignature AccessionSignature DescriptionInterpro AccessionInterpro DescriptionDomain InstanceHuman Domain StartHuman Domain EndHuman Domain LengthPaired ResiduesDomain Reference CoverageDomain Aligned IdentityDomain Identity Coverage Product
Agelaius phoeniceusAvesDNMT1XP_077048462.1PF00145C-5 cytosine-specific DNA methylaseIPR001525C-5 cytosine methyltransferase1115616094544530.99779735682819380.95143487858719640.9493392070484581
Ailuropoda melanoleucaMammalia_nonChiropteraDNMT1XP_011225961.3PF00145C-5 cytosine-specific DNA methylaseIPR001525C-5 cytosine methyltransferase1115616094544541.00.97136563876651980.9713656387665198
Alectura lathamiAvesDNMT1NXL95466.1PF00145C-5 cytosine-specific DNA methylaseIPR001525C-5 cytosine methyltransferase1115616094541670.367841409691630.92814371257485030.341409691629956
Alligator mississippiensisReptiliaDNMT1XP_059588198.1PF00145C-5 cytosine-specific DNA methylaseIPR001525C-5 cytosine methyltransferase1115616094544380.96475770925110130.93835616438356160.9052863436123347
Alligator sinensisReptiliaDNMT1XP_025059761.1PF00145C-5 cytosine-specific DNA methylaseIPR001525C-5 cytosine methyltransferase1115616094544530.99779735682819380.94260485651214130.9405286343612335
Ammodramus caudacutusAvesDNMT1XP_058677345.1PF00145C-5 cytosine-specific DNA methylaseIPR001525C-5 cytosine methyltransferase1115616094544530.99779735682819380.95364238410596030.9515418502202643
Anolis carolinensisReptiliaDNMT1XP_008117963.2PF00145C-5 cytosine-specific DNA methylaseIPR001525C-5 cytosine methyltransferase1115616094544530.99779735682819380.94039735099337750.9383259911894273
Anseranas semipalmataAvesDNMT1NXI71866.1PF00145C-5 cytosine-specific DNA methylaseIPR001525C-5 cytosine methyltransferase1115616094541650.36343612334801760.93333333333333330.33920704845814975
Artibeus jamaicensisMammalia_ChiropteraDNMT1XP_036985019.2PF00145C-5 cytosine-specific DNA methylaseIPR001525C-5 cytosine methyltransferase1115616094544530.99779735682819380.97130242825607060.9691629955947136
Balaenoptera acutorostrataMammalia_nonChiropteraDNMT1XP_057396752.1PF00145C-5 cytosine-specific DNA methylaseIPR001525C-5 cytosine methyltransferase1115616094544530.99779735682819380.96688741721854310.9647577092511014
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Supplementary Data 25 Targeted Domain Conservation Pgls source data

52 materialized released rows from submission:submission-0874a5a043ddb0a424e0af00:1/nature-bird-lifespan-data-v1.0.0.zip!/Supplementary_Data/Supplementary_Data_25_targeted_domain_conservation_pgls.tsv.

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Supplementary Data 25 Targeted Domain Conservation Pgls source data

52 materialized released rows from submission:submission-0874a5a043ddb0a424e0af00:1/nature-bird-lifespan-data-v1.0.0.zip!/Supplementary_Data/Supplementary_Data_25_targeted_domain_conservation_pgls.tsv.

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Test FamilyScopeHuman Gene SymbolPredictorNLambdaLambda MethodEstimate Per SdSeConf LowConf HighTPFit NoteErrorQQ Gene Scope All Metrics
domain_aggregateall_species_min5domain_aggregateaggregate_domain_contrast_clade_z510.780268999078616maximum_likelihood0.06025517087196490.0312318323635522-0.0009592205605973780.1214695623045271.929287086667490.05949679989464720.0594967998946472
domain_aggregateall_species_min5domain_aggregateaggregate_domain_gene_clade_z510.806534529463264maximum_likelihood0.02928936030858930.0313183387407883-0.03209458362335580.09067330424053430.9352143659664650.354264115046470.35426411504647
domain_aggregateall_species_min5domain_aggregateaggregate_domain_gene_z510.796461343567351maximum_likelihood0.04769881792310810.0523072592096552-0.05482341012781620.1502210459740320.9118967165135570.3662877974303060.366287797430306
domain_aggregateall_species_min8domain_aggregateaggregate_domain_contrast_clade_z460.771079078740101maximum_likelihood0.05070886376283290.0354610581587372-0.0187948102282920.1202125377539581.429987326825970.159783594221270.15978359422127
domain_aggregateall_species_min8domain_aggregateaggregate_domain_gene_clade_z460.77686861061142maximum_likelihood0.01340464170614850.0365993495645978-0.05833008344046320.08513936685276010.3662535500115730.715931142621970.71593114262197
domain_aggregateall_species_min8domain_aggregateaggregate_domain_gene_z460.773542347362833maximum_likelihood0.01145622317667590.0575571967640165-0.1013558824807960.1242683288341480.1990406729439270.8431478557791090.843147855779109
domain_aggregateaves_min5domain_aggregateaggregate_domain_contrast_clade_z171e-06maximum_likelihood0.07862828166789390.03910181119156510.001988731732426390.1552678316033612.01086034819930.06267067635809090.0626706763580909
domain_aggregateaves_min5domain_aggregateaggregate_domain_gene_clade_z170.443344782638132maximum_likelihood0.05338258360921420.0410878594334545-0.02714962088035650.1339147880987851.29923009729120.2134806157395150.213480615739515
domain_aggregateaves_min5domain_aggregateaggregate_domain_gene_z170.321230615500601maximum_likelihood0.05432797726385550.0406449916332677-0.02533620633734920.133992160865061.336646289758080.2012596652100620.201259665210062
domain_aggregateaves_min8domain_aggregateaggregate_domain_contrast_clade_z141e-06maximum_likelihood0.03556384231413030.0466290530858499-0.05582910173413550.1269567863623960.762697073188530.4603744925096010.460374492509601
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Supplementary Data 26 Samhd1 Domain Robustness source data

36 materialized released rows from submission:submission-0874a5a043ddb0a424e0af00:1/nature-bird-lifespan-data-v1.0.0.zip!/Supplementary_Data/Supplementary_Data_26_samhd1_domain_robustness.tsv.

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Supplementary Data 26 Samhd1 Domain Robustness source data

36 materialized released rows from submission:submission-0874a5a043ddb0a424e0af00:1/nature-bird-lifespan-data-v1.0.0.zip!/Supplementary_Data/Supplementary_Data_26_samhd1_domain_robustness.tsv.

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ScopePredictorNPredictor CenterPredictor ScaleLambdaLambda MethodEstimate Per SdSeConf LowConf HighTPFit NoteErrorQ Within Scope
all_speciesdomain_minus_nondomain_product53-0.01191652230909690.05171638121281691e-06maximum_likelihood0.1279860905030070.02965045316279030.06987120230393790.1861009787020764.316496945268367.30353793771954e-050.000292141517508782
all_speciesdomain_identity_coverage_product530.6692307692307690.1141950514955530.727825239872756maximum_likelihood0.2083955002736070.06598635487261190.07906224472328770.3377287558239263.158160511759120.002667262014046210.00533452402809242
all_specieswhole_protein_identity_coverage_product530.6786726143830250.09357584660841880.800123445303648maximum_likelihood0.1187366964412110.0832977769510362-0.04452694638282050.2820003392652411.425448562823060.1601195143571240.213492685809499
all_speciesnondomain_identity_coverage_product530.6811472915398660.09049321943176020.752850591156449maximum_likelihood0.05068557141266850.0787205937438783-0.1036067923253330.204977935150670.6438667317166930.5225469909223190.522546990922319
birds_onlydomain_minus_nondomain_product20-0.04608405707196030.05054308398284661e-06maximum_likelihood0.132459542831790.04685487971432610.04062397859171120.2242951070718692.827017028736290.01117019117623120.0341861238179484
birds_onlydomain_identity_coverage_product200.5461538461538460.05467835794699311e-06maximum_likelihood0.1257609476589760.04786934928366620.03193702306299040.2195848722549622.627170612112080.01709306190897420.0341861238179484
birds_onlywhole_protein_identity_coverage_product200.5826677316293930.01901368204503441e-06maximum_likelihood0.08266713775557870.0528249244086471-0.02086971408536960.1862039895965271.564926759119920.1350108042220920.180014405629456
birds_onlynondomain_identity_coverage_product200.5922379032258060.01425430916731291e-06maximum_likelihood0.01273223814909170.0562238965250045-0.09746659903991710.12293107533810.2264559899975850.8233985087115250.823398508711525
domain_coverage_ge_0.8domain_minus_nondomain_product48-0.001082376964433430.04017898778577581e-06maximum_likelihood0.1087430044837510.02944753406204170.05102583772214930.1664601712453533.692771158856470.0005870606821825050.00234824272873002
domain_coverage_ge_0.8domain_identity_coverage_product480.6899038461538460.09848603738277040.757028581747695maximum_likelihood0.1573941494994010.0683749267895290.02337929299192460.2914090060068782.301927868733090.02591712195404660.0518342439080932
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Supplementary Data 27 Samhd1 Leave One Species Out source data

106 materialized released rows from submission:submission-0874a5a043ddb0a424e0af00:1/nature-bird-lifespan-data-v1.0.0.zip!/Supplementary_Data/Supplementary_Data_27_samhd1_leave_one_species_out.tsv.

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Supplementary Data 27 Samhd1 Leave One Species Out source data

106 materialized released rows from submission:submission-0874a5a043ddb0a424e0af00:1/nature-bird-lifespan-data-v1.0.0.zip!/Supplementary_Data/Supplementary_Data_27_samhd1_leave_one_species_out.tsv.

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ScopePredictorNPredictor CenterPredictor ScaleLambdaLambda MethodEstimate Per SdSeConf LowConf HighTPFit NoteErrorOmitted SpeciesBaseline NBaseline EstimateBaseline PDelta Estimate
leave_one_species_outdomain_identity_coverage_product520.6692307692307690.1141950514955531e-06fixed_near_zero_optimizer_fallback0.08008987964320630.03304742227569860.0153169319828370.1448628273035762.423483410447420.0190336802590163Problem with optim:52ERROR: ABNORMAL_TERMINATION_IN_LNSRCHCrocodylus porosus530.2083955002736070.00266726201404621-0.128305620630401
leave_one_species_outdomain_identity_coverage_product520.6692307692307690.1141950514955530.751662950517285maximum_likelihood0.1519398005084250.06403572014837530.02642978901760930.2774498119992412.372735094668560.0215437588201164Pedionomus torquatus530.2083955002736070.00266726201404621-0.056455699765182
leave_one_species_outdomain_identity_coverage_product520.6692307692307690.1141950514955530.755545319876219maximum_likelihood0.234229249898930.07447056282020260.0882669467713330.3801915530265273.145259563358470.0027928410986815Macaca mulatta530.2083955002736070.002667262014046210.0258337496253231
leave_one_species_outdomain_identity_coverage_product520.6692307692307690.1141950514955530.745688473892174maximum_likelihood0.2322177515361870.06971672368012480.09557297312314220.3688625299492313.330875854144430.00163305040961692Eurypyga helias530.2083955002736070.002667262014046210.0238222512625798
leave_one_species_outdomain_identity_coverage_product520.6692307692307690.1141950514955530.712973267671182maximum_likelihood0.1872570532773020.06584932937799960.05819236769642320.3163217388581822.843719974768120.0064428284103375Heterocephalus glaber530.2083955002736070.00266726201404621-0.0211384469963044
leave_one_species_outdomain_identity_coverage_product520.6692307692307690.1141950514955530.743274607134113maximum_likelihood0.2292177776835580.06862508228565240.09471261640367930.3637229389634373.340145760837670.00158920797944484Caprimulgus carolinensis530.2083955002736070.002667262014046210.020822277409951
leave_one_species_outdomain_identity_coverage_product520.6692307692307690.1141950514955530.894896984907421maximum_likelihood0.2289299876180660.06849640839099510.09467702717171580.3631829480644173.342218854910980.00157955704957002Chelonia mydas530.2083955002736070.002667262014046210.0205344873444593
leave_one_species_outdomain_identity_coverage_product520.6692307692307690.1141950514955530.711688354264188maximum_likelihood0.1950372330670610.06632903616867920.06503232217645010.3250421439576732.940450281398160.00495239348362242Dromaius novaehollandiae530.2083955002736070.00266726201404621-0.0133582672065456
leave_one_species_outdomain_identity_coverage_product520.6692307692307690.1141950514955530.610006990227033maximum_likelihood0.1955516211911970.06371162386625180.07067683841334380.3204264039690513.069324078157450.0034620795242768Rhinolophus hipposideros530.2083955002736070.00266726201404621-0.0128438790824096
leave_one_species_outdomain_identity_coverage_product520.6692307692307690.1141950514955530.649738208380159maximum_likelihood0.1958275055466440.0638197894067170.07074071830947910.320914292783813.06844487214860.00347064349458437Alligator mississippiensis530.2083955002736070.00266726201404621-0.0125679947269626
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Supplementary Data 28 Curated Ortholog Rule Eligibility source data

4 materialized released rows from submission:submission-0874a5a043ddb0a424e0af00:1/nature-bird-lifespan-data-v1.0.0.zip!/Supplementary_Data/Supplementary_Data_28_curated_ortholog_rule_eligibility.tsv.

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Supplementary Data 28 Curated Ortholog Rule Eligibility source data

4 materialized released rows from submission:submission-0874a5a043ddb0a424e0af00:1/nature-bird-lifespan-data-v1.0.0.zip!/Supplementary_Data/Supplementary_Data_28_curated_ortholog_rule_eligibility.tsv.

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Ortholog RuleOverall Curated FractionMin Clade FractionMax Clade FractionMax Minus Min Clade FractionSpecies Fraction SdAdequate Min Clade CoverageBalanced Across CladesNondegenerate Species VariationEligible As Primary Full Matrix Control
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Scholarly publication

Si Li, Yanyan Huang. Sequence-audited comparative genomics of genome-maintenance genes in vertebrate lifespan evolution. 10.5281/zenodo.20798437.

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https://github.com/jackeikee-debug/nature-bird-lifespan, commit bf6ac86b961d575f3524b994dcce9fff993637be.

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